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Fat First - With Calorie Capture Technology
Fat First Weight Loss Through Fat Absorbing Calorie Reduction Technology
 
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Description Ingredients Support Documents (Monograph)
 
Fat First - Supporting Weight Management Through Fat-absorbing Calorie Capture Technology
2 Tablets (2 Grams) Absorb as much as 18 Grams of Dietary Fat

Fat First contains FBCx®, a naturally occurring, patented dietary fiber. FBCx® has been researched for over a decade.

While typical dietary fibers adhere to dietary fat in an approximate 1:1 ratio, the FBCx® in Fat First has demonstrated an impressive fat absorbing capability of up to 1:9.

Each serving (2 tablets) of Fat First capture up to 18 grams of dietary fat (equal to about 162 calories).

The FBCx®-fat complex passes through the digestive tract without being absorbed and is eliminated without unpleasant side effects.

When taken with meals or snacks three times per day, Fat First can help manage weight by preventing the absorption of up to 486 calories a day (about 54 grams of dietary fat).

Fat First
also assists in supporting a normal blood lipid profile. Clinical studies show that Fat First assists in supporting healthy triglyceride and cholesterol levels, and helps to restrict the rise of serum triglycerides after meals and snacks.*


Features & FAQs



What is Fat First?

Fat First is a dietary supplement containing the naturally occurring soluble fiber alpha-cyclodextrin, patented as FBCx®. It has been shown to provide support for weight management, healthy lipid levels, and glucose tolerance. FBCx® is a cyclic oligosaccharide with a truncated cone shape that efficiently complexes dietary fats within its conical structure. While typical dietary fibers adhere to dietary fat in an approximate 1:1 ratio, FBCx® has demonstrated an impressive fat-complexing capability of up to 1:9. Two tablets of Fat First may be taken with meals or snacks three times per day. Each serving of Fat First provides 2 grams of FBCx®, which sequesters up to 18 grams of dietary fat (equal to about 162 calories). When taken as directed, Fat First can prevent the absorption of up to 486 dietary calories per day. The FBCx®-fat inclusion complex passes through the digestive tract without being absorbed and is eliminated without unpleasant side effects.


How much dietary fat is prevented from being absorbed when taken as directed?

Each two-tablet serving of Fat First sequesters up to 18 grams of dietary fat (equal to about 162 calories) preventing its digestion and absorption. While typical dietary fibers adhere to dietary fat in an approximate 1:1 ratio, FBCx® has demonstrated an impressive fat-complexing capability of up to 1:9. When taken as directed, Fat First can prevent the absorption up to 486 dietary calories per day.


Does Fat First treat all fats equally?

Animal studies suggest Fat First may have a greater sequestering affinity for saturated fats and trans fatty acids. Regulatory reviews of the FBCx® alpha-cyclodextrin in Fat First conclude that it is unlikely to impair absorption of fat-soluble vitamins and medications. In one human study, it had no effect on serum vitamin D3 levels.


Does diet need to be altered when taking Fat First?

Fat First can be safely added to a balanced and nutritious diet. Two tablets of Fat First may be taken with meals or snacks three times per day. Best supportive results will be observed when Fat First is combined with a sensible calorie-restricting diet and exercise program.


Can Fat First be useful for individuals at a normal weight/BMI index?


Fat First may be an important adjunct to the maintenance of optimal body weight. Thus, individuals who are at a normal weight/BMI index can safely take this product as a valuable addition to a healthy weight management program. In addition to weight management, Fat First offers additional health benefits.


What are the health benefits of Fat First, other than weight management?

By inhibiting dietary fat absorption, Fat First can support healthy triglyceride and cholesterol levels and attenuate the rise of serum triglycerides after meals or snacks. Fat First also has a dose-dependent effect on glucose tolerance and insulin sensitivity. Its favorable effect on glucose metabolism may be due to an ability to complex and inhibit pancreatic alpha-amylase.


What is the suggested use for Fat First?

Adults take 2 tablets with meals or snacks three times per day. Ensure adequate intake of water when taking Fat First. The best supportive results will be observed when Fat First is combined with a sensible calorie-restricting diet and exercise program.


Does Fat First contain allergens?


Fat First is free of the following common allergens: milk/casein, eggs, fish, shellfish, tree nuts, peanuts, wheat/ gluten, yeast, and soybeans. It does not contain artificial colors, flavors, or preservatives.


Does Fat First contain stimulants?

No, Fat First is stimulant-free.


Are there any negative reactions to Fat First?

When taken as recommended – 2 tablets with meals or snacks three times per day with adequate intake of water – no negative effects have been reported.

Are there any side effects?

Fat First prevents dietary fat absorption by surrounding and sequestering the fatty acid tails of di- and triglycerides within its conical structure. Fat First's fat inclusion complex cannot be broken down by human digestive enzymes and so it passes through the small intestine unabsorbed into the colon. Microbial alpha-amylases hydrolyze Fat First in the colon and both Fat First and the triglycerides are largely fermented by the colonic microbiota. Unlike lipase inhibitors, Fat First does not cause excessive fat in the stool (steatorrhea).


Are there adverse reactions or drug interactions?


None reported when taken as directed.


Is Fat First safe to take when pregnant or nursing?

We do not recommend pregnant or nursing women take Fat First.


Should a high-fiber diet be avoided while taking Fat First?


Other fibers are not efficacious in complexing dietary fat. Therefore, there is no need to avoid a high-fiber diet. Fat First with FBCx® can be counted as part of your daily fiber intake. Each serving contains 2 grams of fiber.


Has Fat First been approved by the FDA?


The FDA has designated the GRAS (Generally Recognized As Safe) status to FBCx® alpha-cyclodextrin, supplied in Fat First.


How are the benefits of Fat First verified?

FBCx® was patented by two professors from the Department of Nutrition and Food Science and Department of Pathology of Wayne State University in Detroit, Michigan. A research project involving an obese animal model identified that one gram of FBCx® sequesters and eliminates 9 grams of dietary fat. It also showed the beneficial effects of FBCx® on body weight management, as well as improved glycemic control. These beneficial effects were later verified in clinical trials with overweight healthy adults.


Are there clinical trials that show Fat First supports healthy weight?


Yes. In one trial, 66 obese diabetic subjects were randomized to take two 1-gram tablets of FBCx® (Fat First) or placebo with every fat-containing meal and followed for three months. All participants had been gaining weight at the rate of 2.2 ± 0.88 lbs per month before entry into the study. People who received Fat First stabilized their weight while those on placebo continued to gain weight. When weight change was normalized for dietary energy intake, people receiving Fat First lost weight. The most weight loss occurred in people consuming Fat First in conjunction with reduced energy intake. Fat First had less impact on weight in diabetics taking insulin although it still reduced daily energy intake by 237 calories as compared to 522 calories for noninsulin users. In a double-blind, crossover study involving 41 healthy, but overweight adults, FBCx® (Fat First) alone facilitated significant weight loss over two months without diet or exercise. Although none of the participants reduced their energy intake, people receiving Fat First lost on average a little less than 1 lb during the treatment period compared to controls.


Do clinical trials show that Fat First aids healthy lipid levels?

The effect of Fat First on serum lipid levels is largely dependent on whether dyslipidemia is present. In the clinical trial involving diabetics, Fat First significantly lowered cholesterol levels if hypertriglyceridemia was present. The decrease in total cholesterol was attributable to a reduction in low density lipoprotein (LDL) cholesterol. No change in HDL-cholesterol was observed. Fasting serum triglycerides were reduced in people not using insulin although the change did not attain statistical significance. In the study of healthy, but overweight adults, Fat First significantly lowered total cholesterol and LDL-cholesterol levels in subjects with hypercholesterolemia and hypertriglyceridemia. It also effectively reduced circulating apolipoprotein B, a lipoprotein strongly associated with atherosclerotic vascular plaque and coronary heart disease. In a study of 34 individuals, 2 grams of Fat First significantly lowered postprandial triglycerides following a standardized meal. Elevated nonfasting triglycerides are an independent risk factor for ischemic heart disease and death. Animal studies suggest Fat First may have a greater sequestering affinity for saturated fats and trans fatty acids.


What effect did Fat First have on glucose tolerance and insulin sensitivity in the clinical trials?

Fat First has a dose-dependent effect on glucose tolerance and insulin sensitivity. When taken by healthy people with 50 grams of digestible starch, 5- and 10-gram doses reduce the incremental area under the curve (iAUC) for postprandial glucose. A 2-gram dose also flattened the glucose iAUC, although there were too few subjects to reach statistical significance. Studies show that cyclodextrins complex and inhibit pancreatic alpha-amylase indicating a mechanism whereby Fat First can reduce postprandial glucose loads. Among healthy, but overweight people, Fat First decreased insulin levels by nearly 9.5% consistent with improved insulin sensitivity. In people with obesity and diabetes, Fat First increases adiponectin levels especially in those not using insulin. Higher adiponectin levels favorably impact insulin tolerance, glucose regulation, and weight reduction.



* These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.

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